Medication List; Q & A; About Ischemic Stroke. Currently, there is a lack of sufficient clinical evidence demonstrating that ACE inhibitors or ARBs have any impact on the susceptibility of individuals to SARS-CoV-2 or on the severity or outcomes of infection. Purpose. There are several different ways to summarize concomitant medication data: Preferred term, ATC Text, Indication by Preferred term, and various other combinations. HFSA/ACC/AHA statement addresses concerns re: using RAAS antagonists in COVID-19. Below is a list of common medications used to treat or reduce the symptoms of concomitant hypertension and osteoarthritis. The Concomitant Medications module was one of the group of variables included in the third round of the CRF Harmonization and Standardization Initiative. The link to Table 69 above can be used for more information on PA requirements and evaluation criteria. Some drugs may interact with the study intervention and must not be taken during the study. Patel AB, Verma A. COVID-19 and angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: what is the evidence? Collecting concomitant medications taken during a study is also important for safety reasons. https://www.covid19treatmentguidelines.nih.gov/concomitant-medications Concomitant : Medications / Therapies: List all Medications administered: during the treatment & follow-up periods: Medication / Non-Drug Therapy. The time frame that constitutes the same time varies according to desired effect of the drug, the half-life of each drug administered, the metabolism of each drug, the excretion of each drug and the side effects of each drug individually and collectively. Pharmacists can create a personalized "concomitant-medication review guide" listing key medication-use information in table format to assist other clinicians in preventing and assessing DDIs during a patient's clinical trial participation. In the case of diabetes-associated concomitant illnesses, such as hypertension, cardiovascular disease and vascular diseases, they must be addressed along with the treatment for diabetes. Concomitant administration of ACE inhibitors with potassium -sparing diuretics has been associated with severe hyperkalemia. Rasagiline ( Azilect ): Used to treat symptoms of Parkinson’s disease. A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants. In severe pneumonia caused by influenza, corticosteroid therapy may lead to worse clinical outcomes, including secondary bacterial infection and mortality.7. Preliminary clinical trial data from a large, randomized, open-label trial suggest that dexamethasone reduces mortality in hospitalized patients with COVID-19 who require mechanical ventilation or supplemental oxygen.8 The recommendations for using corticosteroids in patients with COVID-19 depend on the severity of illness. Concomitant drug therapy may alter insulin requirements. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? American College of Cardiology. This was essential to avoid adverse reactions between two drugs that were known to exist. Effect of dexamethasone in hospitalized patients with COVID-19: preliminary report. Gyamfi-Bannerman C, Thom EA, Blackwell SC, et al. In mid-March 2020, news agencies promoted reports that anti-inflammatory drugs may worsen COVID-19. We have a small list of ATC codes with multiples Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Angiotensin-converting enzyme 2 (ACE2) is the cell surface receptor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Procarbazine ( Matulane ): Used in addition to other medications to treat Hodgkin’s disease. (NCI) CDISC CDASH Concomitant Medication Dose Form Terminology: AEROSOL: C42887: aer Concomitant medications were always important for the inclusion and exclusion criteria used to allow patients to take part in trials. Drugs that may decrease insulin requirements include alcohol, anabolic steroids, aspirin, fenfluramine and monoamine oxidase inhibitors; there have been isolated reports of decreased insulin requirements with captopril, clofibrate, cyclophosphamide, guanethidine, mebendazole, methandienone and oxytetracycline. Liggins GC, Howie RN. Concomitant medications (a.k.a., con-meds) are other prescription medications, over-the-counter (OTC) drugs or dietary supplements that a study participant takes in addition to the drug under investigation. When tabulating concomitant medications it is often necessary to categorize data by preferred term. PK ! How to use concomitant in a sentence. Selegiline ( Eldepryl, Zelapar ): May be used for the treatment of Parkinson’s disease in addition to other medications. Concomitant drugs refer to two or more drugs or medications taken at the same time. Record all concomitant medications from baseline as specified in the protocol. The treatment of these other diseases has an effect on blood sugar levels, so the patient's usual diabetes treatment may have to be changed. If a patient is taking a medication PRN, do not use a separate line for each time the medication is taken, instead report the first and last dates taken. Concomitant Opioid Benzodiazepine Initiative See Table 69 Please see the links below for a description of the Concomitant Opioid Benzodiazepine Initiative (COBI), including a medication list and frequently asked questions. Kaiser UB, Mirmira RG, Stewart PM. Purpose. Record all concomitant medications, including therapies given to treat adverse events. This designation is used when medicinal drugs are given either at the same time or almost at the same time. �Hۼ� . Antenatal betamethasone for women at risk for late preterm delivery. In outbreaks of other novel coronavirus infections5,6 (i.e., Middle East respiratory syndrome [MERS] and SARS), corticosteroid therapy was associated with delayed virus clearance. Concomitant medications (a.k.a., con-meds) are other prescription medications, over-the-counter (OTC) drugs or dietary supplements that a study participant takes in addition to the drug under investigation. See Corticosteroids for a detailed discussion of these recommendations. A GENERIC NAME OF MEDICATION B If medication Some drugs may interact with the study intervention and must not be taken during the study. Variable Variable Name Question Field Type (Validation Type) Code List; CMYN: Any meds? Conclusion: Each investigational drug and new drug class in oncology has a unique DDI profile. Did You Know? The Concomitant Medications Report details the information captured on a particular Concomitant Medication iCRF. A short course of betamethasone and dexamethasone, which are corticosteroids known to cross the placenta, is routinely used to hasten fetal lung maturity and decrease the risk of neonatal respiratory distress syndrome in the premature infant with threatened delivery.10,11. Corticosteroids as adjunctive therapy in the treatment of influenza. Concomitant illnesses may make it more difficult for the treating physician to determine the diagnosis or treatment of the primary illness. This is often the case in medicine. It has been proposed that these agents have a potential role in managing patients with severe COVID-19.12 Observational studies have reported that statin therapy may reduce cardiovascular morbidity in patients admitted with other respiratory infections, such as influenza and bacterial pneumonia. Before initiating dexamethasone, clinicians should review the patient’s medical history and assess the potential risks and benefits of administering corticosteroids to the patient. Con-meds may be used by study subjects … Available at: Siddiqi HK, Mehra MR. COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal. https://treatmentwithcbd.com/15-medications-cbd-drug-interactions First, medications with multiple codes are re-listed with all of their codes. When a subject takes aspirin to relieve a toothache, it still inhibits platelet action. DOSE/UNIT/ FREQ; Start Date; End Date or CONT. update, PA will be required in situations where members fill opioid and benzodiazepine medications for at least 60 days within a 90-day period. Make a new entry when a dosage and/or frequency change occurs. Hiding in plain sight: an approach to treating patients with severe COVID-19 infection. To import this instrument please follow the instructions here. How this categorization occurs is a commonly misunderstood process. It has been proposed that NSAIDs such as ibuprofen can increase the expression of ACE21 and inhibit antibody production.13 Shortly after these reports, the Food and Drug Administration stated that there is no evidence linking the use of NSAIDs with worsening of COVID-19 and advised patients to use NSAIDs as directed.14, Statement on Casirivimab Plus Imdevimab EUA, Chloroquine or Hydroxychloroquine With or Without Azithromycin, Clinical Data: Chloroquine or Hydroxychloroquine, Lopinavir/Ritonavir and Other HIV Protease Inhibitors, Table 2 Characteristics of Antiviral Agents, Table 3a Immune-Based Therapy Clinical Data, Table 3b Characteristics of Immune-Based Therapy, https://www.ncbi.nlm.nih.gov/pubmed/32171062, https://www.ncbi.nlm.nih.gov/pubmed/32208485, https://www.acc.org/latest-in-cardiology/articles/2020/03/17/08/59/hfsa-acc-aha-statement-addresses-concerns-re-using-raas-antagonists-in-covid-19, https://www.ncbi.nlm.nih.gov/pubmed/32362390, https://www.ncbi.nlm.nih.gov/pubmed/29161116, https://www.ncbi.nlm.nih.gov/pubmed/16968120, https://www.ncbi.nlm.nih.gov/pubmed/26950335, https://www.medrxiv.org/content/10.1101/2020.06.22.20137273v1, https://www.ncbi.nlm.nih.gov/pubmed/32232480, https://www.ncbi.nlm.nih.gov/pubmed/4561295, https://www.ncbi.nlm.nih.gov/pubmed/26842679, https://www.ncbi.nlm.nih.gov/pubmed/32198163, https://www.ncbi.nlm.nih.gov/pubmed/19345936, https://www.fda.gov/drugs/drug-safety-and-availability/fda-advises-patients-use-non-steroidal-anti-inflammatory-drugs-nsaids-covid-19, Persons with COVID-19 who are prescribed ACE inhibitors or ARBs for cardiovascular disease (or other indications) should continue these medications, The COVID-19 Treatment Guidelines Panel (the Panel), On the basis of the preliminary report from the Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial, the Panel recommends using, If dexamethasone is not available, the Panel recommends using alternative glucocorticoids such as, Oral corticosteroid therapy that was used prior to COVID-19 diagnosis for another underlying condition (e.g., primary or secondary adrenal insufficiency, rheumatological diseases) should not be discontinued, Inhaled corticosteroids that are used daily for patients with asthma and chronic obstructive pulmonary disease for control of airway inflammation should not be discontinued in patients with COVID-19, Given the potential benefit of decrease in maternal mortality and the low risk of fetal adverse effects for this short course of therapy, the Panel recommends using, Persons with COVID-19 who are prescribed statin therapy for the treatment or prevention of cardiovascular disease should continue these medications, Persons with COVID-19 who are taking NSAIDs for a comorbid condition should continue therapy as previously directed by their physician, The Panel recommends that there be no difference in the use of antipyretic strategies (e.g., with acetaminophen or NSAIDs) between patients with or without COVID-19, Persons with COVID-19 who are prescribed angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs) for cardiovascular disease (or other indications) should continue these medications, Persons with COVID-19 who are taking nonsteroidal anti-inflammatory drugs (NSAIDs) for a comorbid condition should continue therapy as previously directed by their physician, The Panel recommends that there be no difference in the use of antipyretic strategirs (e.g., with acetaminophen or NSAIDs) between patients with or without COVID-19. , Verma A. 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